Difference between revisions of "Enzymes"
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Revision as of 18:21, 21 October 2012
Enzymes generally make excellent targets for small molecule ligand discovery because
- they are pre-organized to carry out a reaction and thus have destabilizing unsatisfied residues that are available for ligand binding
- there is often a chemical starting point available in the form of the endogenous ligand
- there is hope that interfering with catalysis will have an effect because a bound ligand directly competes with the natrual substrate.
Back to targets.