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Paragigm Docking
Developer Shoichet Lab
Stable Version SEA
Programming Language TBD
Dependencies TBD

SEA, the Similarity Ensemble Approach. The website is:


SEA relates proteins based on the set-wise chemical similarity among their ligands. It can be used to rapidly search large compound databases and to build cross-target similarity maps. It is provided by the Shoichet Laboratory in the Department of Pharmaceutical Chemistry at the University of California, San Francisco (UCSF).

Citing SEA

To cite SEA, please reference Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Relating protein pharmacology by ligand chemistry. Nat Biotech 25 (2), 197-206 (2007)[1].


Using the SEA website

Obtaining a private copy of SEA

Please contact support(at)sea*bkslab*org

Other topics


Caveat Emptor! SEA is provided free-of-charge in the hope that it will be useful, but you must use it at your own risk. We make no guarantees about data confidentiality on this public service website. If you would like to use SEA securely, please contact support+sea*bkslab*org.

To determine whether SEA's predictions for your compounds are already known, we recommend you visit the extensive Ki Database at the NIMH Psychoactive Drug Screening Program[2].



This category has only the following subcategory.


  • SEA(1 C, 8 P)

Pages in category "SEA"

The following 8 pages are in this category, out of 8 total.